Why GELX

Create an effective bioactive barrier with GELX

  • OM barrier therapy biomechanically protects against intraoral pain, coating exposed nerve endings and open sores1,2
  • Polyvinylpyrrolidone delivery system helps to improve the release rate and solubility of drugs (eg, the GELX Zinc-Taurine Complex)1

GELX supplies the mucosal environment with a bioactive Zinc-Taurine Complex known to help hinder and delay the inflammatory cycle1

THE ANTI-INFLAMMATORY EFFECTS

ZINC
  • Zinc has demonstrated anti-inflammatory and antioxidant benefits and has been shown to lessen the severity of mucositis3-5
TAURINE
  • Taurine plays an important role in inflammation associated with oxidative stress and has many cytoprotective attributes6,7

The combined anti-inflammatory properties of zinc and taurine have demonstrated a synergistic biological effect in vitro1,8

How GELX works

The anti-inflammatory action1

1
Adheres to mucosal surface and delivers a bioactive Zinc-Taurine Complex
2
Releases bioactive Zinc-Taurine Complex into epithelial cells
3
Zinc and taurine penetrate submucosa and may help to regulate COX-2–mediated prostaglandins and inflammatory cytokines
BIOMECHANICAL BENEFITS1,2
4
Provides a bioadhesive barrier for durable protection
5
Blocks exposed nerve endings and coats oral lesions to soothe and relieve pain
6
Protects ulcerated tissue from further insult and bacterial colonization

GELX relieves pain—targets the inflammatory response

Provides consistent pain relief that helps patients complete cancer treatment goals9,10

Consistent
daily intervals of soothing pain relief2

Greater
oral comfort enables good nutrition and hydration

Durable
protection from secondary infections and injuries

Safety profile allows for use throughout the entire cancer treatment cycle1

Important Safety Information
  • GELX is contraindicated in any patient with a known history of hypersensitivity to any of the ingredients.
  • Patients should not use if stick pack has been opened prior to receipt or is damaged in any way.
  • Patients should not eat or drink for at least one hour after use.
  • If no improvement is seen in 7 days, patients are encouraged to consult their physician.

References: 1. Data on file. USWM, LLC; Louisville, KY: 2019. 2. GELX® ORAL GEL Prescribing Information. USWM, LLC; Louisville, KY: 2019. 3. Prasad AS. Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care. 2009;12:646-652. 4. Lin L-C, Que J, Lin L-K, Lin F-C. Zinc supplementation to improve mucositis and dermatitis in patients after radiotherapy for head-and-neck cancers: a double-blind, randomized study. Int J Radiat Oncol. 2006;65(3):745-750. 5. Arbabi-kalati F, Arbabi-kalati F, Deghatipour M, Moghaddam AA. Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: a double-blind, randomized clinical trial. Arch Iran Med. 2012;15(7):413-417. 6. Marcinkiewicz J, Kontny E. Taurine and inflammatory diseases [published online ahead of print July 19, 2012]. Amino Acids. Doi:10.1007/s00726-012-1361-4. 7. Ripps H, Shen W. Review: Taurine: a “very essential” amino acid. Mol Vis. 2012;18:2673-2686. 8. Pasantes-Morales H, Wright CE, Gaull GE. Protective effect of taurine, zinc and tocopherol on retinol-induced damage in human lymphoblastoid cells. J Nutr. 1984;114(12):2256-2261. 9. Naidu MU, Ramana GV, Rani PU, Mohan IK, Suman A, Roy P. Chemotherapy-induced and/or radiation therapy-induced oral mucositis—complicating the treatment of cancer. Neoplasia. 2004;6(5)423-431. 10. Peterson DE, Cariello A. Mucosal damage: a major risk factor for severe complications after cytotoxic therapy. Semin Oncol. 2004;31(3 suppl 8):35-44.

INDICATION

GELX ORAL GEL has a mechanical action indicated for the management of pain and relief of pain, by adhering to the mucosal surface of the mouth, soothing oral lesions of various etiologies, including: Oral Mucositis/Stomatitis (may be caused by chemotherapy or radiotherapy), irritation due to oral surgery, traumatic ulcers caused by braces or ill-fitting dentures, or disease. Also indicated for diffuse aphthous ulcers.

IMPORTANT SAFETY INFORMATION

  • GELX is contraindicated in any patient with a known history of hypersensitivity to any of the ingredients.
  • Patients should not use if stick pack has been opened prior to receipt or is damaged in any way.
  • Patients should not eat or drink for at least one hour after use.
  • If no improvement is seen in 7 days, patients are encouraged to consult their physician.

To report SUSPECTED ADVERSE REACTIONS or product complaints, contact US WorldMeds at 1-855-797-9232.
You may also report SUSPECTED ADVERSE REACTIONS to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

Please see full Prescribing Information.

GELX is a registered trademark of Sunstar Suisse SA. USWM, LLC is the exclusive licensee and distributor of GELX in the United States and Its territories. All other trademarks are property of their respective owners.